Conservation of k-mer Composition and Correlation Contribution between Introns and Intergenic Regions of Animalia Genomes.

ABSTRACT: In this study, we pairwise-compared multiple genome regions, including genes, exons, coding DNA sequences (CDS), introns, and intergenic regions of 39 Animalia genomes, including Deuterostomia (27 species) and Protostomia (12 species), by applying established k-mer-based (alignment-free) comparison methods. We found strong correlations between the sequence structure of introns and intergenic regions, individual organisms, and within wider phylogenetical ranges, indicating the conservation of certain structures over the full range of analyzed organisms. We analyzed these sequence structures by quantifying the contribution of different sets of DNA words to the average correlation value by decomposing the correlation coefficients with respect to these word sets. We found that the conse

SUBMITTER: Sievers A 

PROVIDER: S-EPMC6211125 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature