Scaling-up HCV prevention and treatment interventions in rural United States-model projections for tackling an increasing epidemic.

ABSTRACT:

Background and aims

Effective strategies are needed to address dramatic increases in hepatitis C virus (HCV) infection among people who inject drugs (PWID) in rural settings of the United States. We determined the required scale-up of HCV treatment with or without scale-up of HCV prevention interventions to achieve a 90% reduction in HCV chronic prevalence or incidence by 2025 and 2030 in a rural US setting.

Design

An ordinary differential equation model of HCV transmission calibrated to HCV epidemiological data obtained primarily from an HIV outbreak investigation in Indiana.

Setting

Scott County, Indiana (population 24 181), USA, a rural setting with negligible baseline interventions, increasing HCV epidemic since 2010, and 55.3% chronic HCV prevalence among PWID in

SUBMITTER: Fraser H 

PROVIDER: S-EPMC6211174 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature