HIV transmission in discordant couples in Africa in the context of antiretroviral therapy availability.

ABSTRACT:

Objective

The study aims to understand the basis of continued HIV-1 transmission in Zambian and Rwandan HIV-1-discordant couples in the context of antiretroviral therapy (ART).

Design

We identified nine Zambian and seven Rwandan acutely infected, epidemiologically-linked couples from government couples' voluntary counseling and testing (CVCT) clinics where transmitting partners reported being on ART near the time of transmission.

Methods

We quantified viral load and plasma antiretroviral drug concentrations near the time of transmission and used these as surrogate measures for adherence. We also sequenced the polymerase gene from both donor and recipient partners to determine the presence of drug resistance mutations (DRMs).

Results

In Zambia, all transmitting

SUBMITTER: Woodson E 

PROVIDER: S-EPMC6211178 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature