Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens.

ABSTRACT: Invasive fungal infections due to Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans constitute a substantial threat to hospitalized immunocompromised patients. Further, the presence of drug-recalcitrant biofilms on medical devices and emergence of drug-resistant fungi, such as Candida auris, introduce treatment challenges with current antifungal drugs. Worse, currently there is no approved drug capable of obviating preformed biofilms, which increase the chance of infection relapses. Here, we screened a small-molecule New Prestwick Chemical Library, consisting of 1,200 FDA-approved off-patent drugs against C. albicans, C. auris, and A. fumigatus, to identify those that inhibit growth of all three pathogens. Inhibitors were

SUBMITTER: Mamouei Z 

PROVIDER: S-EPMC6211222 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature