Impact of intravenous exenatide infusion for perioperative blood glucose control on myocardial ischemia-reperfusion injuries after coronary artery bypass graft surgery: sub study of the phase II/III ExSTRESS randomized trial.

ABSTRACT:

Background

The aim of the study was to investigate whether intravenous (iv) infusion of exenatide, a synthetic GLP-1 receptor agonist, could provide a protective effect against myocardial ischemia-reperfusion injury after coronary artery bypass graft (CABG) surgery.

Methods

A sub study analysis of patients > 18 years admitted for elective CABG and included in the ExSTRESS trial was conducted. Patients were randomized to receive either iv exenatide (1-h bolus of 0.05 µg min^-1 followed by a constant infusion of 0.025 µg min^-1) (exenatide group) or iv insulin therapy (control group) for blood glucose control (target range 100-139 mg dl^-1) during the first 48 h after surgical incision. All serum levels of troponin I measured during routine care i

SUBMITTER: Besch G 

PROVIDER: S-EPMC6211400 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature