Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles.

ABSTRACT:

Background

Small extracellular vesicles (small-EVs) are membranous vesicles that contain unique information regarding the condition of cells and contribute to the recruitment and reprogramming of components associated with the tumor environment. Therefore, many researchers have suggested that small-EV proteins are potential biomarkers for diseases such as cancer. Colon cancer (CC) is one of the most common causes of cancer-related deaths worldwide. Biomarkers such as carcinoembryonic antigen (CEA) show low sensitivity (~ 40%), and thus the demand for novel biomarkers for CC diagnosis is increasing.

Methods

In this study, we identified biomarkers for diagnosing CC through proteomic analysis of small-EVs from CC cell lines. These small-EVs were characterized by western blot an

SUBMITTER: Lee CH 

PROVIDER: S-EPMC6211419 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature