Spread of the florfenicol resistance floR gene among clinical Klebsiella pneumoniae isolates in China.

ABSTRACT:

Background

Florfenicol is a derivative of chloramphenicol that is used only for the treatment of animal diseases. A key resistance gene for florfenicol, floR, can spread among bacteria of the same and different species or genera through horizontal gene transfer. To analyze the potential transmission of resistance genes between animal and human pathogens, we investigated floR in Klebsiella pneumoniae isolates from patient samples. floR in human pathogens may originate from animal pathogens and would reflect the risk to human health of using antimicrobial agents in animals.

Methods

PCR was used to identify floR-positive strains. The floR genes were cloned, and the minimum inhibitory concentrations (MICs) were determined to assess the r

SUBMITTER: Lu J 

PROVIDER: S-EPMC6211440 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature