Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis.

ABSTRACT:

Background

Zuojinwan (ZJW), a classic herbal formula, has been extensively used to treat gastric symptoms in clinical practice in China for centuries. However, the pharmacological mechanisms of ZJW still remain vague to date.

Methods

In the present work, a network pharmacology-based strategy was proposed to elucidate its underlying multi-component, multi-target, and multi-pathway mode of action against gastritis. First we collected putative targets of ZJW based on TCMSP and STITCH databases, and a network containing the interactions between the putative targets of ZJW and known therapeutic targets of gastritis was built. Then four topological parameters, "degree", "betweenness", "closeness", and "coreness" were calculated to identify the major targets in the network. Further

SUBMITTER: Yu G 

PROVIDER: S-EPMC6211468 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature