Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice.

ABSTRACT:

Background

It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL.

Methods

Diet-induced obese (DIO) mice raised on a 60% calories from fat diet and control mice were implanted with syngeneic ALL cells. Some DIO mice were switched to the low-fat control diet. Survival from ALL was assessed without or with chemotherapy treatment starting at the time of the diet switch. Cells from DIO mice before and after diet switch were assessed by FACS for BrdU incorporati

SUBMITTER: Tucci J 

PROVIDER: S-EPMC6211598 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature