Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project.

ABSTRACT:

Background

Use of selective COX-2 non-steroidal anti-inflammatory drugs (NSAIDs) (coxibs) has been associated with an increased risk of acute myocardial infarction (AMI). However, the risk of AMI has only been studied for very few NSAIDs that are frequently used.

Objectives

To estimate the risk of AMI for individual NSAIDs.

Methods

A nested case-control study was performed from a cohort of new NSAID users ≥18 years (1999-2011) matching cases to a maximum of 100 controls on database, sex, age, and calendar time. Data were retrieved from six healthcare databases. Adjusted odds ratios (ORs) of current use of individual NSAIDs compared to past use were estimated per database. Pooling was done by two-stage pooling using a random effects model (ORmeta) and by one-stage pool

SUBMITTER: Masclee GMC 

PROVIDER: S-EPMC6211656 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature