Miniature pig magnetic resonance spectroscopy model of normal adolescent brain development.

ABSTRACT:

Background

We are developing the miniature pig (Sus scrofa domestica), an in-vivo translational, gyrencephalic model for brain development, as an alternative to laboratory rodents/non-human primates. We analyzed longitudinal changes in adolescent pigs using proton magnetic resonance spectroscopy (¹H-MRS) and examined the relationship with white matter (WM) integrity derived from diffusion weighted imaging (DWI).

New method

Twelve female Sinclair^™ pigs underwent three imaging/spectroscopy sessions every 23.95 ± 3.73 days beginning at three months of age using a clinical 3 T scanner. ¹H-MRS data were collected using 1.2 × 1.0 × 3.0 cm voxels placed in left and right hemisphere WM using a Point Resolved Spectroscopy sequence (TR = 2000 ms, TE = 

SUBMITTER: Ryan MC 

PROVIDER: S-EPMC6211793 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature