Transition between fermentation and respiration determines history-dependent behavior in fluctuating carbon sources.

ABSTRACT: Cells constantly adapt to environmental fluctuations. These physiological changes require time and therefore cause a lag phase during which the cells do not function optimally. Interestingly, past exposure to an environmental condition can shorten the time needed to adapt when the condition re-occurs, even in daughter cells that never directly encountered the initial condition. Here, we use the molecular toolbox of Saccharomyces cerevisiae to systematically unravel the molecular mechanism underlying such history-dependent behavior in transitions between glucose and maltose. In contrast to previous hypotheses, the behavior does not depend on persistence of proteins involved in metabolism of a specific sugar. Instead, presence of glucose induces a gradual decline in the cells' ability to act

SUBMITTER: Cerulus B 

PROVIDER: S-EPMC6211830 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature