The distinguishable DNA whole genome methylation profile of 2 cases of pediatric precursor B acute lymphoblastic leukaemia (BCP ALL) with prodromal, preleukemic phase: A case report.

ABSTRACT:

Rationale

A prolonged, prodromal phase before definitive paediatric precursor B acute lymphoblastic leukaemia (BCP ALL) diagnosis is rarely observed.

Patients concerns

In the first, the patient presented with an aplastic preleukemic phase, whilst the second presented with a rheumatic-like preliminary phase.

Diagnoses

The case reports of two patients with BCP ALL with a prodromal phase lasting a few weeks are presented.

Interventions and outcomes

DNA whole genome profile methylation analysis of bone marrow cells obtained at diagnosis revealed a pattern of methylation that was readily distinguishable from both healthy and standard course BCP ALL bone marrow samples.

Lessons

The biological implication of this observation remains unclear, with many different

SUBMITTER: Chaber R 

PROVIDER: S-EPMC6211912 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature