Base-free nickel-catalysed decarbonylative Suzuki-Miyaura coupling of acid fluorides.

ABSTRACT: The Suzuki-Miyaura cross-coupling of organoboron nucleophiles with aryl halide electrophiles is one of the most widely used carbon-carbon bond-forming reactions in organic and medicinal chemistry^1,2. A key challenge associated with these transformations is that they generally require the addition of an exogenous base, the role of which is to enable transmetallation between the organoboron nucleophile and the metal catalyst³. This requirement limits the substrate scope of the reaction because the added base promotes competitive decomposition of many organoboron substrates^3-5. As such, considerable research has focused on strategies for mitigating base-mediated side reactions^6-12. Previous efforts have primarily focused either on designing strategi

SUBMITTER: Malapit CA 

PROVIDER: S-EPMC6212315 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature