A cortico-cerebellar loop for motor planning.

ABSTRACT: Persistent and ramping neural activity in the frontal cortex anticipates specific movements^1-6. Preparatory activity is distributed across several brain regions^7,8, but it is unclear which brain areas are involved and how this activity is mediated by multi-regional interactions. The cerebellum is thought to be primarily involved in the short-timescale control of movement^9-12; however, roles for this structure in cognitive processes have also been proposed^13-16. In humans, cerebellar damage can cause defects in planning and working memory¹³. Here we show that persistent representation of information in the frontal cortex during motor planning is dependent on the cerebellum. Mice performed a sensory discrimination task in which they used

SUBMITTER: Gao Z 

PROVIDER: S-EPMC6212318 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature