Molecular signature of the putative stem/progenitor cells committed to the development of the bovine mammary gland at puberty.

ABSTRACT: Milk production is highly dependent on the extensive development of the mammary epithelium, which occurs during puberty. It is therefore essential to distinguish the epithelial cells committed to development from the related epithelial hierarchy. Using cell phenotyping and sorting, we highlighted four cell sub-populations within the bovine mammary gland at puberty. The CD49_f^highCD24^neg cells expressing CD10, KRT14, vimentin and PROCR corresponded to cells committed to the basal lineage. The CD49_f^low sub-population contained two cell subsets (CD49_f^lowCD24^neg and CD49_f^lowCD24^pos). Both subsets expressed hormone receptors including ER, PR and PRLR, as well as ALDH1 activity

SUBMITTER: Finot L 

PROVIDER: S-EPMC6212573 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature