High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions.

ABSTRACT: Streptococcus pneumoniae is an opportunistic human pathogen that typically colonizes the nasopharyngeal passage and causes lethal disease in other host niches, such as the lung or the meninges. The expression and regulation of pneumococcal genes at different life-cycle stages, such as commensal or pathogenic, are not entirely understood. To chart the transcriptional responses of S. pneumoniae, we used RNA-seq to quantify the relative abundance of the transcriptome under 22 different infection-relevant conditions. The data demonstrated a high level of dynamic expression and, strikingly, all annotated pneumococcal genomic features were expressed in at least one of the studied conditions. By computing the correlation values of every pair of genes across all studied conditions, we created a co

SUBMITTER: Aprianto R 

PROVIDER: S-EPMC6212715 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature