Sex Differences in the Methylome and Transcriptome of the Human Liver and Circulating HDL-Cholesterol Levels.

ABSTRACT:

Context

Epigenetics may contribute to sex-specific differences in human liver metabolism.

Objective

To study the impact of sex on DNA methylation and gene expression in human liver.

Design/setting

Cross-sectional, Kuopio Obesity Surgery Study.

Participants/intervention

We analyzed DNA methylation with the Infinium HumanMethylation450 BeadChip in liver of an obese population (34 males, 61 females). Females had a higher high-density lipoprotein (HDL)-cholesterol levels compared with males. Gene expression was measured with the HumanHT-12 Expression BeadChip in a subset of 42 participants.

Results

Females displayed higher average methylation in the X-chromosome, whereas males presented higher methylation in autosomes. We found 9455 CpG sites in the X-chromo

SUBMITTER: Garcia-Calzon S 

PROVIDER: S-EPMC6212806 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature