Ontology highlight
ABSTRACT:
SUBMITTER: Lu J
PROVIDER: S-EPMC6212842 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Lu Jianping J Xu Juan J Li Junyi J Pan Tao T Bai Jing J Wang Liqiang L Jin Xiyun X Lin Xiaoyu X Zhang Yunpeng Y Li Yongsheng Y Sahni Nidhi N Li Xia X
Nucleic acids research 20181101 19
Epigenetic alterations, a well-recognized cancer hallmark, are driven by chromatin regulators (CRs). However, little is known about the extent of CR deregulation in cancer, and less is known about their common and specialized roles across various cancers. Here, we performed genome-wide analyses and constructed molecular signatures and network profiles of functional CRs in over 10 000 tumors across 33 cancer types. By integration of DNA mutation, genome-wide methylation, transcriptional/post-tran ...[more]