Combinatorial Surface Roughness Effects on Osteoclastogenesis and Osteogenesis.

ABSTRACT: Implant surface properties are a key factor in bone responses to metallic bone implants. In view of the emerging evidence on the important role of osteoclasts in bone regeneration, we here studied how surface roughness affects osteoclastic differentiation and to what extent these osteoclasts have stimulatory effects on osteogenic differentiation of osteoprogenitor cells. For this, we induced osteoclasts derived from RAW264.7 cell line and primary mouse macrophages on titanium surfaces with different roughness ( R_a 0.02-3.63 μm) and analyzed osteoclast behavior in terms of cell number, morphology, differentiation, and further anabolic effect on osteoblastic cells. Surfaces with different roughness induced the formation of osteoclasts with distinct phenotypes, based on total osteo

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6213029 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature