Hypermethylation of CCND2 in Lung and Breast Cancer Is a Potential Biomarker and Drug Target.

ABSTRACT: Lung and breast cancer are the leading causes of mortality in women worldwide. The discovery of molecular alterations that underlie these two cancers and corresponding drugs has contributed to precision medicine. We found that CCND2 is a common target in lung and breast cancer. Hypermethylation of the CCND2 gene was reported previously; however, no comprehensive study has investigated the clinical significance of CCND2 alterations and its applications and drug discovery. Genome-wide methylation and quantitative methylation-specific real-time polymerase chain reaction (PCR) showed CCND2 promoter hypermethylation in Taiwanese breast cancer patients. As compared with paired normal tissues and healthy individuals, CCND2 promoter hypermethylation was detected in 40.9

SUBMITTER: Hung CS 

PROVIDER: S-EPMC6213171 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature