Unknown

Dataset Information

0

Chrysoxanthones A⁻C, Three New Xanthone⁻Chromanone Heterdimers from Sponge-Associated Penicillium chrysogenum HLS111 Treated with Histone Deacetylase Inhibitor.


ABSTRACT: By treating with histone-deacetylase inhibitor valproate sodium, three new heterdimeric tetrahydroxanthone⁻chromanone lactones chrysoxanthones A⁻C (1⁻3), along with 17 known compounds were isolated from a sponge-associated Penicillium chrysogenum HLS111. The planar structures of chrysoxanthones A⁻C were elucidated by means of spectroscopic analyses, including MS, 1D, and 2D NMR. Their absolute configurations were established by electronic circular dichroism (ECD) calculations. Chrysoxanthones A⁻C exhibited moderate antibacterial activities against Bacillus subtilis with minimum inhibitory concentration (MIC) values of 5⁻10 μg/mL.

SUBMITTER: Zhen X 

PROVIDER: S-EPMC6213349 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

altmetric image

Publications

Chrysoxanthones A⁻C, Three New Xanthone⁻Chromanone Heterdimers from Sponge-Associated <i>Penicillium chrysogenum</i> HLS111 Treated with Histone Deacetylase Inhibitor.

Zhen Xin X   Gong Ting T   Wen Yan-Hua YH   Yan Dao-Jiang DJ   Chen Jing-Jing JJ   Zhu Ping P  

Marine drugs 20181001 10


By treating with histone-deacetylase inhibitor valproate sodium, three new heterdimeric tetrahydroxanthone⁻chromanone lactones chrysoxanthones A⁻C (<b>1</b>⁻<b>3</b>), along with 17 known compounds were isolated from a sponge-associated <i>Penicillium chrysogenum</i> HLS111. The planar structures of chrysoxanthones A⁻C were elucidated by means of spectroscopic analyses, including MS, 1D, and 2D NMR. Their absolute configurations were established by electronic circular dichroism (ECD) calculation  ...[more]

Similar Datasets

| S-EPMC6182556 | biostudies-literature
| S-EPMC7464707 | biostudies-literature
| PRJNA110889 | ENA
| PRJNA120297 | ENA
| PRJNA145557 | ENA
| PRJNA353579 | ENA
| PRJNA587307 | ENA
| PRJNA132945 | ENA
| PRJNA147549 | ENA
| PRJNA131227 | ENA