Exploring the Remote Ties between Helitron Transposases and Other Rolling-Circle Replication Proteins.

ABSTRACT: Rolling-circle replication (RCR) elements constitute a diverse group that includes viruses, plasmids, and transposons, present in hosts from all domains of life. Eukaryotic RCR transposons, also known as Helitrons, are found in species from all eukaryotic kingdoms, sometimes representing a large portion of their genomes. Despite the impact of Helitrons on their hosts, knowledge about their relationship with other RCR elements is still elusive. Here, we compared the endonuclease domain sequence of Helitron transposases with the corresponding region from RCR proteins found in a wide variety of mobile genetic elements. To do that, we used a stepwise alignment approach followed by phylogenetic and multidimensional scaling analyses. Although it has been suggested that Helitrons might have origi

SUBMITTER: Heringer P 

PROVIDER: S-EPMC6213432 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature