Effect of Low-Fat Diet in Obese Mice Lacking Toll-like Receptors.

ABSTRACT: Background: This study aimed at assessing the effect of a low-fat diet (LFD) in obese mice lacking toll⁻like receptors (Tlr) and understanding the expression and regulation of microRNAs during weight reduction. Methods: C57BL/6, Tlr5^-/-, Tlr2^-/- and Tlr4^-/- mice were used in this study. A group of mice were fed with a high-fat diet (HFD) (58% kcal) for 12 weeks to induce obesity (diet-induced obesity, DIO). Another group that had been fed with HFD for eight weeks (obese mice) were switched to a low-fat diet (LFD) (10.5% kcal) for the next four weeks to reduce their body weight. The control mice were fed with a standard AIN-76A diet for the entire 12 weeks. The body weight of the mice was measured weekly. At the end of the experiment, epididyma

SUBMITTER: Rau CS 

PROVIDER: S-EPMC6213519 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature