3D Bone Biomimetic Scaffolds for Basic and Translational Studies with Mesenchymal Stem Cells.

ABSTRACT: Mesenchymal stem cells (MSCs) are recognized as an attractive tool owing to their self-renewal and differentiation capacity, and their ability to secrete bioactive molecules and to regulate the behavior of neighboring cells within different tissues. Accumulating evidence demonstrates that cells prefer three-dimensional (3D) to 2D culture conditions, at least because the former are closer to their natural environment. Thus, for in vitro studies and in vivo utilization, great effort is being dedicated to the optimization of MSC 3D culture systems in view of achieving the intended performance. This implies understanding cell⁻biomaterial interactions and manipulating the physicochemical characteristics of biomimetic scaffolds to elicit a specific cell behavior. In the bone field, biomimetic sc

SUBMITTER: Sobacchi C 

PROVIDER: S-EPMC6213614 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature