Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender.

ABSTRACT: Chemerin (also known as tazarotene-induced gene 2 and retinoic acid receptor responder 2) has been identified as an adipokine that exerts effects on many biological processes, including adipogenesis, angiogenesis, inflammation, immune responses, and food intake. This variety of effects has led to its implication in obesity and co-morbidities including diabetes and a risk of cardiovascular disease. The biological effects are mostly mediated by a so-called G protein-coupled receptor, chemokine-like receptor 1 (CMKLR1). Given the association of chemerin with obesity and related diseases, we decided to study in detail the regulation of chemerin and CMKLR1 expression in white adipose tissue (WAT). Specifically, we focused on their expression levels in physiological and pathophysiological settin

SUBMITTER: Sanchez-Rebordelo E 

PROVIDER: S-EPMC6213800 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature