G Protein-Coupled Receptor Systems as Crucial Regulators of DNA Damage Response Processes.

ABSTRACT: G protein-coupled receptors (GPCRs) and their associated proteins represent one of the most diverse cellular signaling systems involved in both physiological and pathophysiological processes. Aging represents perhaps the most complex biological process in humans and involves a progressive degradation of systemic integrity and physiological resilience. This is in part mediated by age-related aberrations in energy metabolism, mitochondrial function, protein folding and sorting, inflammatory activity and genomic stability. Indeed, an increased rate of unrepaired DNA damage is considered to be one of the 'hallmarks' of aging. Over the last two decades our appreciation of the complexity of GPCR signaling systems has expanded their functional signaling repertoire. One such example of this is the

SUBMITTER: Leysen H 

PROVIDER: S-EPMC6213947 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature