Tissue-Specific Profiling of Oxidative Stress-Associated Transcriptome in a Healthy Mouse Model.

ABSTRACT: Oxidative stress is a common phenomenon and is linked to a wide range of diseases and pathological processes including aging. Tissue-specific variation in redox signaling and cellular responses to oxidative stress may be associated with vulnerability especially to age-related and chronic diseases. In order to provide a basis for tissue-specific difference, we examined the tissue-specific transcriptional features of 101 oxidative stress-associated genes in 10 different tissues and organs of healthy mice under physiological conditions. Microarray analysis results, which were consistent with quantitative polymerase chain reaction (qPCR) results, showed that catalase, Gpx3, and Gpx4 were most highly regulated in the liver, kidney, and testes. We also found the tissue-specific gene expression o

SUBMITTER: Kim JM 

PROVIDER: S-EPMC6214011 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature