Thrombospondin-1 Is Necessary for the Development and Repair of Corneal Nerves.

ABSTRACT: Thrombospondin-1-deficient (TSP-1^-/-) mice are used as an animal model of Sjögren's Syndrome because they exhibit many of the symptoms associated with the autoimmune type of dry eye found in primary Sjögren's Syndrome. This type of dry eye is linked to the inflammation of the lacrimal gland, conjunctiva, and cornea, and is thought to involve dysfunction of the complex neuronal reflex arc that mediates tear production in response to noxious stimuli on the ocular surface. This study characterizes the structural and functional changes to the corneal nerves that are the afferent arm of this arc in young and older TSP-1^-/- and wild type (WT) mice. The structure and subtype of nerves were characterized by immunohistochemistry, in vivo confocal microscopy, and confocal micro

SUBMITTER: Tatematsu Y 

PROVIDER: S-EPMC6214039 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature