Endometrial Intracrinology: Oestrogens, Androgens and Endometrial Disorders.

ABSTRACT: Peripheral tissue metabolism of steroids (intracrinology) is now accepted as a key way in which tissues, such as the endometrium, can utilise inactive steroids present in the blood to respond to local physiological demands and 'fine-tune' the activation or inhibition of steroid hormone receptor-dependent processes. Expression of enzymes that play a critical role in the activation and inactivation of bioactive oestrogens (E1, E2) and androgens (A4, T, DHT), as well as expression of steroid hormone receptors, has been detected in endometrial tissues and cells recovered during the menstrual cycle. There is robust evidence that increased expression of aromatase is important for creating a local microenvironment that can support a pregnancy. Measurement of intra-tissue concentrations of steroid

SUBMITTER: Gibson DA 

PROVIDER: S-EPMC6214123 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature