Associations Among Dietary Fat Oxidation Responses to Overfeeding and Weight Gain in Obesity-Prone and Resistant Adults.

ABSTRACT:

Objective

This study tested the hypothesis that 3 days of overfeeding (OF) decreases dietary fat oxidation and predicts longitudinal weight change in adults classified as obesity prone (OP) and obesity resistant (OR) based on self-identification and personal and family weight history. Changes in diurnal profiles of plasma metabolites and hormones were measured to probe mechanisms.

Methods

Adults identified as OP (n = 22; BMI: 23.9  ±  2.4 kg/m² ) and OR (n = 30; BMI: 20.5  ±  2.2 kg/m² ) completed 3 days of eucaloric (EU) feeding and 3 days of OF. On day 3, the 24-hour total and dietary fat oxidation was measured using room calorimetry and an oral ¹⁴ C tracer. Plasma glucose, insulin, triglycerides, and nonesterified fatty acid (NEFA) concent

SUBMITTER: Rynders CA 

PROVIDER: S-EPMC6214358 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature