An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors.

ABSTRACT: An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described. This synthesis represents a practical and enantioselective entry to a range of other dipeptide isosteres, which are not limited to amino acid derived substituents.

SUBMITTER: Ghosh AK 

PROVIDER: S-EPMC6214462 | biostudies-literature | 1991 Nov

REPOSITORIES: biostudies-literature