Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice.

ABSTRACT:

Background

Cortical spreading depolarization (CSD) is a phenomenon classically associated with migraine aura. CSDs have also been implicated in secondary injury following ischemic stroke, intracerebral hemorrhage, subarachnoid hemorrhage, and traumatic brain injury; however, most investigations involving these disease processes do not account for the occurrence of CSDs. A major barrier to detection of CSDs in experimental models is that currently validated methods are invasive and require specialized equipment and a high level of expertise to implement.

New method

We present a low-cost, easy-to-implement approach to the detection of CSDs in the mouse through full-thickness intact skull. Our method uses the optical intrinsic signal from white light illumination (OIS-WL) and a

SUBMITTER: Chung DY 

PROVIDER: S-EPMC6214472 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature