Ontology highlight
ABSTRACT:
SUBMITTER: Louveau A
PROVIDER: S-EPMC6214619 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Nature neuroscience 20180917 10
Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic phenotype and trigger disease remains, however, unclear. The existence of lymphatic vessels in the meninges indicates a relevant link between the CNS and peripheral immune system, perhaps affecting autoimmunity. Here we demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainag ...[more]