Ontology highlight
ABSTRACT:
SUBMITTER: Hrit J
PROVIDER: S-EPMC6214653 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
eLife 20181016
TET enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine and higher oxidized derivatives. TETs stably associate with and are post-translationally modified by the nutrient-sensing enzyme OGT, suggesting a connection between metabolism and the epigenome. Here, we show for the first time that modification by OGT enhances TET1 activity in vitro. We identify a TET1 domain that is necessary and sufficient for binding to OGT and report a point mutation that disrupts the TET1-OGT interaction. We ...[more]