Response Gene to Complement 32 Maintains Blood Pressure Homeostasis by Regulating α-Adrenergic Receptor Expression.

ABSTRACT:

Rationale

Hypertension prevalence is much higher among children and adolescents with low birth weight and greater postnatal weight gain than in individuals with normal birth weight. However, the cause and molecular mechanisms underlying this complication remain largely unknown. Our previous studies have shown that RGC-32 (response gene to complement 32)-deficient (RGC-32^-/-) mice are born significantly smaller but grow faster than their WT (wild type) controls, which allows adult RGC-32^-/- mice to attain body weights similar to those of control mice.

Objective

The objective of this study is to determine whether RGC-32^-/- mice develop hypertension, and if so, to elucidate the underlying mechanisms.

Methods and results

By using a radiote

SUBMITTER: Tang JM 

PROVIDER: S-EPMC6214659 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature