Bioscaffold-mediated mucosal remodeling following short-segment colonic mucosal resection.

ABSTRACT: Precancerous or cancerous lesions of the gastrointestinal tract often require surgical resection via endomucosal resection. Although excision of the colonic mucosa is an effective cancer treatment, removal of large lesions is associated with high morbidity and complications including bleeding, perforation, fistula formation, and/or stricture, contributing to high clinical and economic costs and negatively impacting patient quality of life. The present study investigates the use of a biologic scaffold derived from extracellular matrix (ECM) to promote restoration of the colonic mucosa following short segment mucosal resection. Six healthy dogs were assigned to ECM-treated (tubular ECM scaffold) and mucosectomy only control groups following transanal full circumferential mucosal resection (4

SUBMITTER: Dziki JL 

PROVIDER: S-EPMC6214663 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature