Genetic determinants of childhood and adult height associated with osteosarcoma risk.

ABSTRACT:

Background

Although increased height has been associated with osteosarcoma risk in previous epidemiologic studies, to the authors' knowledge the relative contribution of stature during different developmental timepoints remains unclear. Furthermore, the question of how genetic determinants of height impact osteosarcoma etiology remains unexplored. Genetic variants associated with stature in previous genome-wide association studies may be biomarkers of osteosarcoma risk.

Methods

The authors tested the associations between osteosarcoma risk and polygenic scores for adult height (416 variants), childhood height (6 variants), and birth length (5 variants) in 864 osteosarcoma cases and 1879 controls of European ancestry.

Results

Each standard deviation increase in the poly

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6214707 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature