Selective modulation of brain network dynamics by seizure therapy in treatment-resistant depression.

ABSTRACT:

Background

Electroconvulsive therapy (ECT) is highly effective for treatment-resistant depression, yet its mechanism of action is still unclear. Understanding the mechanism of action of ECT can advance the optimization of magnetic seizure therapy (MST) towards higher efficacy and less cognitive impairment. Given the neuroimaging evidence for disrupted resting-state network dynamics in depression, we investigated whether seizure therapy (ECT and MST) selectively modifies brain network dynamics for therapeutic efficacy.

Methods

EEG microstate analysis was used to evaluate resting-state network dynamics in patients at baseline and following seizure therapy, and in healthy controls. Microstate analysis defined four classes of brain states (labelled A, B, C, D). Source localizati

SUBMITTER: Atluri S 

PROVIDER: S-EPMC6214861 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature