Decreased subregional specificity of the putamen in Parkinson's Disease revealed by dynamic connectivity-derived parcellation.

ABSTRACT: Parkinson's Disease (PD) is associated with decreased ability to perform habitual tasks, relying instead on goal-directed behaviour subserved by different cortical/subcortical circuits, including parts of the putamen. We explored the functional subunits in the putamen in PD using novel dynamic connectivity features derived from resting state fMRI recorded from thirty PD subjects and twenty-eight age-matched healthy controls (HC). Dynamic functional segmentation of the putamina was obtained by determining the correlation between each voxel in each putamen along a moving window and applying a joint temporal clustering algorithm to establish cluster membership of each voxel at each window. Contiguous voxels that had consistent cluster membership across all windows were then considered to be p

SUBMITTER: Liu A 

PROVIDER: S-EPMC6214880 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature