Ontology highlight
ABSTRACT:
SUBMITTER: Liang Y
PROVIDER: S-EPMC6214895 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Liang Yong Y Tang Haidong H Guo Jingya J Qiu Xiangyan X Yang Zecheng Z Ren Zhenhua Z Sun Zhichen Z Bian Yingjie Y Xu Lily L Xu Hairong H Shen Jiao J Han Yanfei Y Dong Haidong H Peng Hua H Fu Yang-Xin YX
Nature communications 20181102 1
Many patients remain unresponsive to intensive PD-1/PD-L1 blockade therapy despite the presence of tumor-infiltrating lymphocytes. We propose that impaired innate sensing might limit the complete activation of tumor-specific T cells after PD-1/PD-L1 blockade. Local delivery of type I interferons (IFNs) restores antigen presentation, but upregulates PD-L1, dampening subsequent T-cell activation. Therefore, we armed anti-PD-L1 antibody with IFNα (IFNα-anti-PD-L1) to create feedforward responses. H ...[more]