Metabolic profiling of adherence to diet, physical activity and body size recommendations for cancer prevention.

ABSTRACT: Maintaining a healthy body weight, eating well and being physically active lowers cancer risk by 30%. However, the biology underlying these relationships is not well understood. We examined cross-sectional associations between metabolites and cancer preventive behaviors as well as the relevance to cancer-related pathways among 120 participants (50% men, mean BMI 26.6 kg/m², mean age 54 years) with no history of smoking or cancer. Participants completed questionnaires, physical measurements and provided blood samples. Non-targeted nuclear magnetic resonance captured 223 metabolite measures. Factor analysis was performed separately for amino acid, fatty acid and lipoprotein groups. Multivariable-adjusted linear regression was used to evaluate associations between cancer preventive

SUBMITTER: Gu Q 

PROVIDER: S-EPMC6214951 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature