Tissue-resident memory T cells populate the human brain.

ABSTRACT: Most tissues are populated by tissue-resident memory T cells (T_RM cells), which are adapted to their niche and appear to be indispensable for local protection against pathogens. Here we show that human white matter-derived brain CD8⁺ T cells can be subsetted into CD103^-CD69⁺ and CD103⁺CD69⁺ T cells both with a phenotypic and transcription factor profile consistent with T_RM cells. Specifically, CD103 expression in brain CD8⁺ T cells correlates with reduced expression of differentiation markers, increased expression of tissue-homing chemokine receptors, intermediate and low expression of the transcription factors T-bet and eomes, increased expression of PD-1 and CTLA-4, and low expression of cytolytic enz

SUBMITTER: Smolders J 

PROVIDER: S-EPMC6214977 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature