Parvalbumin⁺ interneurons obey unique connectivity rules and establish a powerful lateral-inhibition microcircuit in dentate gyrus.

ABSTRACT: Parvalbumin-positive (PV⁺) GABAergic interneurons in hippocampal microcircuits are thought to play a key role in several higher network functions, such as feedforward and feedback inhibition, network oscillations, and pattern separation. Fast lateral inhibition mediated by GABAergic interneurons may implement a winner-takes-all mechanism in the hippocampal input layer. However, it is not clear whether the functional connectivity rules of granule cells (GCs) and interneurons in the dentate gyrus are consistent with such a mechanism. Using simultaneous patch-clamp recordings from up to seven GCs and up to four PV⁺ interneurons in the dentate gyrus, we find that connectivity is structured in space, synapse-specific, and enriched in specific disynaptic motifs. In contrast

SUBMITTER: Espinoza C 

PROVIDER: S-EPMC6214995 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature