Engineering Lineage Potency and Plasticity of Stem Cells using Epigenetic Molecules.

ABSTRACT: Stem cells are considered as a multipotent regenerative source for diseased and dysfunctional tissues. Despite the promise of stem cells, the inherent capacity of stem cells to convert to tissue-specific lineages can present a major challenge to the use of stem cells for regenerative medicine. We hypothesized that epigenetic regulating molecules can modulate the stem cell's developmental program, and thus potentially overcome the limited lineage differentiation that human stem cells exhibit based on the source and processing of stem cells. In this study, we screened a library of 84 small molecule pharmacological agents indicated in nucleosomal modification and identified a sub-set of specific molecules that influenced osteogenesis in human mesenchymal stem cells (hMSCs) while maintaining c

SUBMITTER: Dhaliwal A 

PROVIDER: S-EPMC6215020 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature