A Disposable Blood-on-a-Chip for Simultaneous Measurement of Multiple Biophysical Properties.

ABSTRACT: Biophysical properties are widely used to detect pathophysiological processes of vascular diseases or clinical states. For early detection of cardiovascular diseases, it is necessary to simultaneously measure multiple biophysical properties in a microfluidic environment. However, a microfluidic-based technique for measuring multiple biophysical properties has not been demonstrated. In this study, a simple measurement method was suggested to quantify three biophysical properties of blood, including red blood cell (RBC) deformability, RBC aggregation, and hematocrit. To demonstrate the suggested method, a microfluidic device was constructed, being composed of a big-sized channel (BC), a parallel micropillar (MP), a main channel, a branch channel, inlet, and outlets. By operating a single syr

SUBMITTER: Kang YJ 

PROVIDER: S-EPMC6215101 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature