Variability and reliability of effective connectivity within the core default mode network: A multi-site longitudinal spectral DCM study.

ABSTRACT: Dynamic causal modelling (DCM) for resting state fMRI - namely spectral DCM - is a recently developed and widely adopted method for inferring effective connectivity in intrinsic brain networks. Most applications of spectral DCM have focused on group-averaged connectivity within large-scale intrinsic brain networks; however, the consistency of subject- and session-specific estimates of effective connectivity has not been evaluated. Establishing reliability (within subjects) is crucial for its clinical use; e.g., as a neurophysiological phenotype of disease progression. Effective connectivity during rest is likely to vary due to changes in cognitive, and physiological states. Quantifying these variations may help understand functional brain architectures - and inform clinical applications. I

SUBMITTER: Almgren H 

PROVIDER: S-EPMC6215332 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature