Epigenetic modifications by polyphenolic compounds alter gene expression in the hippocampus.

ABSTRACT: In this study, we developed an experimental protocol leveraging enhanced reduced representation bisulphite sequencing to investigate methylation and gene expression patterns in the hippocampus in response to polyphenolic compounds. We report that the administration of a standardized bioavailable polyphenolic preparation (BDPP) differentially influences methylated cytosine patterns in introns, UTR and exons in hippocampal genes. We subsequently established that dietary BDPP-mediated changes in methylation influenced the transcriptional pattern of select genes that are involved in synaptic plasticity. In addition, we showed dietary BDPP mediated changes in the transcriptional pattern of genes associated with epigenetic modifications, including members of the DNA methyl transferase family (

SUBMITTER: Frolinger T 

PROVIDER: S-EPMC6215408 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature