Functional Parcellation of the Cerebral Cortex Across the Human Adult Lifespan.

ABSTRACT: Adult aging is associated with differences in structure, function, and connectivity of brain areas. Age-based brain comparisons have typically rested on the assumption that brain areas exhibit a similar spatial organization across age; we evaluate this hypothesis directly. Area parcellation methods that identify locations where resting-state functional correlations (RSFC) exhibit abrupt transitions (boundary-mapping) are used to define cortical areas in cohorts of individuals sampled across a large range of the human adult lifespan (20-93 years). Most of the strongest areal boundaries are spatially consistent across age. Differences in parcellation boundaries are largely explained by differences in cortical thickness and anatomical alignment in older relative to younger adults. Despite the

SUBMITTER: Han L 

PROVIDER: S-EPMC6215466 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature