Direct Relay Pathways from Lemniscal Auditory Thalamus to Secondary Auditory Field in Mice.

ABSTRACT: Tonotopy is an essential functional organization in the mammalian auditory cortex, and its source in the primary auditory cortex (A1) is the incoming frequency-related topographical projections from the ventral division of the medial geniculate body (MGv). However, circuits that relay this functional organization to higher-order regions such as the secondary auditory field (A2) have yet to be identified. Here, we discovered a new pathway that projects directly from MGv to A2 in mice. Tonotopy was established in A2 even when primary fields including A1 were removed, which indicates that tonotopy in A2 can be established solely by thalamic input. Moreover, the structural nature of differing thalamocortical connections was consistent with the functional organization of the target regions in t

SUBMITTER: Ohga S 

PROVIDER: S-EPMC6215474 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature